wellness

Nature Medicine, Published online: 11 April 2025; doi:10.1038/s41591-025-03649-z

The World Health Organization’s inaugural Investment Round aims to instill stability in the face of global health headwinds and a US exit.

Nature Medicine, Published online: 11 April 2025; doi:10.1038/s41591-025-03689-5

Author Correction: Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults

Nature Medicine, Published online: 11 April 2025; doi:10.1038/s41591-025-03672-0

A human cellular and molecular atlas of the proliferative endometrium in polycystic ovary syndrome (PCOS) was generated via single-nucleus RNA sequencing and spatial transcriptomics. This study reveals PCOS-specific alterations in cellular composition and gene expression, and identifies potential therapeutic targets. These findings could advance treatments for PCOS-related endometrial dysfunction and associated health challenges.

Nature Medicine, Published online: 10 April 2025; doi:10.1038/d41591-025-00024-w

The success of new non-opioid drugs and other treatments for pain offer some relief for sufferers.

Nature Medicine, Published online: 10 April 2025; doi:10.1038/s41591-025-03638-2

In a phase 1/2 trial in patients with advanced non-small-cell lung cancer (NSCLC), followed by a phase 2 trial in an EGFR-mutant selected population, treatment with the TROP2-targeting antibody–drug conjugate sacituzumab tirumotecan led to encouraging clinical response rates, especially in patients with EGFR-mutant NSCLC, which was supported by mechanistic data.

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Nature Medicine, Published online: 09 April 2025; doi:10.1038/s41591-025-03644-4

Clinical and genomic mapping of a large sample of invasive nontyphoidal Salmonella infections sheds light on the global spread of this pathogen and its acquisition of antimicrobial resistance features and indicates future potential for human-to-human transmission.

Nature Medicine, Published online: 09 April 2025; doi:10.1038/s41591-025-03622-w

Among 1,767 patients in 5 centers, a fully automated blood test showed high accuracy for Alzheimer’s pathology in secondary and primary care using a predefined cutoff.

Nature Medicine, Published online: 09 April 2025; doi:10.1038/s41591-025-03691-x

Author Correction: AI-guided precision parenteral nutrition for neonatal intensive care units

Nature Medicine, Published online: 09 April 2025; doi:10.1038/s41591-025-03690-y

Author Correction: Pay-it-forward incentives for hepatitis virus testing in men who have sex with men: a cluster randomized trial