wellness

Nature Medicine, Published online: 12 February 2026; doi:10.1038/s41591-026-04208-w

A cluster-randomized trial in rural Lesotho showed that uncontrolled hypertension diagnosis and management delivered by minimally trained lay persons in the community using a mobile decision support tool was superior to facility referral for improving clinical outcomes.

Nature Medicine, Published online: 12 February 2026; doi:10.1038/s41591-025-04139-y

A follow-up analysis of a clinical trial that evaluated anti-PD-1 therapy in patients with cancer who are living with HIV provides mechanistic insights into transcriptomic, cellular and cytokine changes related to immune checkpoint inhibitor treatment and identifies a signature associated with clinical response.

Nature Medicine, Published online: 12 February 2026; doi:10.1038/s41591-025-04152-1

PD-1 blockade reprograms both innate and adaptive immunity in people living with HIV and cancer, inducing interferon-driven antiviral responses that reduce the HIV reservoir. A pre-existing type I interferon signature predicts reservoir decline, whereas high TGFβ signaling opposes it, defining immune states that influence the outcome of PD-1 therapy.

Doximity users who met U.S. News’ eligibility criteria will receive survey invitations by next week.

Nature Medicine, Published online: 11 February 2026; doi:10.1038/s41591-025-04178-5

PRIMARY-AI: outcomes-based standards to safeguard primary care in the AI era

Nature Medicine, Published online: 11 February 2026; doi:10.1038/s41591-026-04224-w

Extracorporeal liver cross-circulation using genetically modified pig livers was feasible in a human decedent model, providing effective temporary liver support with minimal immunosuppression. In this model, xenograft integrity was preserved, and metabolic and hemodynamic stability were maintained even after removal of the native human liver in the decedent.

Nature Medicine, Published online: 11 February 2026; doi:10.1038/s41591-026-04216-w

Capillary blood sampling for the Alzheimer’s disease biomarkers p-tau217, NfL and GFAP correlates with venous measures for the same biomarkers. As capillary p-tau217 accurately classified amyloid burden, it might support remote assessment in large-scale epidemiology to estimate the prevalence of Alzheimer’s disease and enable triage into clinical services and trials.

Nature Medicine, Published online: 10 February 2026; doi:10.1038/s41591-026-04261-5

Author Correction: Detection of undiagnosed liver cirrhosis via AI-enabled electrocardiogram: a pragmatic, cluster-randomized clinical trial

A group of scientists from top U.S. university hospitals has determined that calculating body mass index (BMI) alone isn’t enough to designate someone as obese. BMI, which measures body fat using a person’s height and weight, has been the standard criteria for diagnosing obesity for years, but the doctors at Beth Israel, Yale, and Harvard found that accounting for waist circumference, waist-to-hip ratio, and waist-to-height ratio as well provides a better indication of potential obesity. The bad news is that combining waist measurements with BMI means that over 75 percent of adults may be obese, as opposed to 40 percent when using BMI on its own.

Since 2021, U.S. News has collected data from maternity hospitals for its annual evaluation of the Best Hospitals for Maternity Care. This...