wellness

Nature Medicine, Published online: 29 April 2025; doi:10.1038/s41591-025-03653-3

Molecular analyses of longitudinal kidney biopsies from a phase 2 trial testing an anti-CD38 antibody for kidney transplant rejection show temporary suppression of antibody-mediated rejection during treatment, with molecular recurrence at 52 weeks.

Nature Medicine, Published online: 29 April 2025; doi:10.1038/s41591-025-03687-7

The stochasticity of biological aging

Nature Medicine, Published online: 29 April 2025; doi:10.1038/s41591-025-03731-6

Author Correction: Autologous T cell therapy for PRAME⁺ advanced solid tumors in HLA-A*02⁺ patients: a phase 1 trial

Nature Medicine, Published online: 28 April 2025; doi:10.1038/s41591-025-03629-3

Forecast models of bacterial antimicrobial resistance (AMR) surveillance records from 101 countries reveal that the global burden of AMR is associated with the impact of climate change intertwined with the failure to achieve sustainable development goals.

Nature Medicine, Published online: 28 April 2025; doi:10.1038/d41591-025-00027-7

The polygenic score, based on analysis of DNA from a saliva sample, led to the detection of more cancers than would have been found with standard screening pathways.

Nature Medicine, Published online: 28 April 2025; doi:10.1038/s41591-025-03700-z

Proteomics analyses of thousands of proteins in human cerebrospinal fluid reveal that the ratio of two proteins can be used to predict future dementia or cognitive resilience among people with Alzheimer’s disease brain pathology.

Nature Medicine, Published online: 25 April 2025; doi:10.1038/s41591-025-03713-8

Author Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

Nature Medicine, Published online: 25 April 2025; doi:10.1038/s41591-025-03717-4

Author Correction: T cell malignancies after CAR T cell therapy in the DESCAR-T registry

Nature Medicine, Published online: 23 April 2025; doi:10.1038/s41591-025-03639-1

A trial that used a master randomized design found that the skills commonly found in smartphone-based cognitive behavioral therapy, when tested alone or in combination with behavioral activation, were differentially efficacious in improving mental health symptoms in adults with subthreshold depression.

Nature Medicine, Published online: 23 April 2025; doi:10.1038/s41591-025-03647-1

Analysis of multiple cohorts of patients with melanoma demonstrates a positive association between cytomegalovirus serostatus and overall survival in patients treated with monotherapy but not combination immune checkpoint blockade, as well as delayed onset of immune-related adverse events across both treatment types, as well as delayed development of metastatic disease in seropositive patients.