wellness

Nature Medicine, Published online: 22 April 2025; doi:10.1038/s41591-025-03656-0

Administration of an antisense oligonuceotide in a preterm infant with severe early-onset SCN2A developmental and epileptic encephalopathy was well tolerated and led to a 60% decrease in seizure frequency.

Nature Medicine, Published online: 22 April 2025; doi:10.1038/s41591-025-03677-9

Microglia have a central role in the clearance of amyloid-β after immunotherapy in Alzheimer’s disease. By integrating spatial transcriptomics and single-cell RNA sequencing, we identified distinct microglial states that mediate removal of amyloid-β. APOE and TREM2 emerged as key regulators of amyloid-β clearance and indicators of treatment response, and thereby represent potential therapeutic targets.

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Nature Medicine, Published online: 21 April 2025; doi:10.1038/s41591-025-03616-8

In the CRHCP-3 cluster-randomized trial, blood pressure reduction lowered the risk of all-cause dementia by 15% in 33,995 individuals with hypertension.

Nature Medicine, Published online: 18 April 2025; doi:10.1038/s41591-025-03645-3

The authors found, after analyzing 10,960 individuals from 9 multiancestry biobanks across 6 countries, that genetic factors previously associated with BMI have limited impact on GLP-1 receptor agonist-induced weight loss.

Nature Medicine, Published online: 18 April 2025; doi:10.1038/s41591-025-03657-z

A multicohort study finds that social disadvantage is linked to proteomics signatures of aging, helping to explain the association between social disparities and more than 60 age-related diseases.

Nature Medicine, Published online: 18 April 2025; doi:10.1038/s41591-025-03590-1

Helmholtz Health task force to strengthen prevention research and its translation globally

Nature Medicine, Published online: 17 April 2025; doi:10.1038/d41591-025-00026-8

Despite a negative primary outcome, a trial of gantenerumab showed a clinically meaningful slowing of disease onset in asymptomatic people who were treated for the longest duration.

Nature Medicine, Published online: 17 April 2025; doi:10.1038/s41591-025-03673-z

An AI-driven screener for opioid use disorder in hospital settings could increase referrals to addiction services and improve patient outcomes, but it is crucial that treatment is accessible and that unintended harms such as stigma are avoided.

Nature Medicine, Published online: 17 April 2025; doi:10.1038/s41591-025-03718-3

In a patient with treatment-refractory idiopathic inflammatory myositis, re-infusion of CD19 CAR-T cells following disease relapse led to the development of anti-CD19 CAR T cells and no clinical improvement, with drug-free remission induced again after treatment with BCMA CAR-T cells