Nature Medicine, Published online: 20 October 2025; doi:10.1038/s41591-025-04023-9
Researchers analyzed 5,279 plasma proteins in 40 people undergoing feminizing gender-affirming hormone therapy over 6 months, revealing significant changes in 299 proteins. Such changes could have implications for reproductive capacity, immune regulation and long-term health.- October 20, 2025
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Nature Medicine, Published online: 20 October 2025; doi:10.1038/d41591-025-00061-5
Baby wraps treated with the insecticide permethrin reduced the incidence of malaria in infants by 66%, according to a randomized controlled trial in Uganda.- October 20, 2025
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Nature Medicine, Published online: 20 October 2025; doi:10.1038/d41591-025-00063-3
A study shows that creativity enhances brain health by improving connectivity in age-vulnerable regions, highlighting the importance of supporting creative activities in public health strategies.- October 20, 2025
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Nature Medicine, Published online: 19 October 2025; doi:10.1038/s41591-025-04029-3
As presented at the European Society for Medical Oncology Congress 2025: In patients with locally advanced or metastatic solid tumours, including mesothelioma, treatment with a first-in-class inhibitor of the Hippo−YAP−TEAD pathway was safe and led to encouraging clinical response rates in patients with mesothelioma.- October 19, 2025
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Big Tree Farms is entering the BBQ category with its Naughty Bali lineup, crafted from organic coconut nectar and Balinese ingredients sourced through its Fair Trade farmer network. The three sauces range from mellow to volcanic and are now available at Sprouts and select Publix locations.
- October 18, 2025
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Nature Medicine, Published online: 18 October 2025; doi:10.1038/s41591-025-04032-8
As presented at the ASCO 2025 Annual Meeting and the ESMO Congress 2025: In RELATIVITY-098, treatment of patients with stage III/IV resected melanoma with nivolumab and relatlimab compared to nivolumab alone did not significantly change recurrence-free survival, with correlative data pointing to the absence of tumor-infiltrating LAG3+ T cells as a potential reason.- October 18, 2025
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Nature Medicine, Published online: 18 October 2025; doi:10.1038/s41591-025-04022-w
As presented at the ESMO Congress 2025: in this international, single-arm phase 2 trial, first-line treatment of patients with advanced gastric cancer, gastroesophageal junction cancer or esophageal adenocarcinoma with domvanalimab (Fc-silent anti-TIGIT) and zimberelimab (anti-PD-1) plus FOLFOX (oxaliplatin, leucovorin and fluorouracil) led to encouraging objective response rates and survival outcomes, which will be validated in a phase 3 trial.- October 18, 2025
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Nature Medicine, Published online: 18 October 2025; doi:10.1038/s41591-025-03979-y
As presented at the ESMO Congress 2025, in the single-arm phase 2 IKF/AIO PHERFLOT trial, the perioperative combination of FLOT chemotherapy with anti-PD-1 and anti-HER2 monoclonal antibodies led to a pathological complete response rate of 48.4% in patients with resectable HER2+ esophagogastric adenocarcinoma, meeting the prespecified co-primary endpoint.- October 18, 2025
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US sales of certified organic products accelerated in 2024 with an annual growth rate of 5.2%, more than double that of the overall marketplace which grew at 2.5% in the same period. Dollar sales for organic also reached a new high of $71.6 billon in 2024, according to the 2025 Organic Market Report.
- October 16, 2025
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Nature Medicine, Published online: 16 October 2025; doi:10.1038/s41591-025-03976-1
The authors explore the impact of MC4R deficiency on lipid metabolism in humans, based on two large cohorts. Findings indicate that individuals with obesity due to MC4R deficiency have lower cholesterol and triglyceride levels, as well as reduced cardiovascular risk.- October 16, 2025
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