wellness

Nature Medicine, Published online: 16 October 2025; doi:10.1038/s41591-025-04008-8

The latest large language model from OpenAI offers safety gains, persistent risks and the illusion of understanding.

Nature Medicine, Published online: 16 October 2025; doi:10.1038/s41591-025-03941-y

A new study provides physiological insights into the dying process, which could have substantial implications for resuscitation science, death determination and organ donation.

Nature Medicine, Published online: 16 October 2025; doi:10.1038/s41591-025-04024-8

BioCog is a brief, self-administered digital test battery that helps to accurately detect cognitive impairment in primary care patients undergoing evaluation for a possible neurodegenerative disease. When combined with blood biomarker tests, the digital test outperformed current standard-of-care assessments of Alzheimer’s disease, supporting a more precise, efficient and timely diagnosis.

Nature Medicine, Published online: 15 October 2025; doi:10.1038/s41591-025-03993-0

A randomized, controlled phase 1b trial evaluated the safety, pharmacokinetics and impact on viral kinetics of budigalimab, a PD-1 inhibitor, during analytical treatment interruption for HIV and found that it was well tolerated and resulted in delayed rebound in a subset of participants in an exploratory efficacy analysis.

Nature Medicine, Published online: 15 October 2025; doi:10.1038/s41591-025-03991-2

Germany is paving the way toward genomics-based personalized healthcare and translational research.

Nature Medicine, Published online: 15 October 2025; doi:10.1038/s41591-025-04034-6

A multi-center, hospital-based observational study in India evaluated the effectiveness of Rotavac, a locally produced rotavirus vaccine, against laboratory-confirmed rotavirus gastroenteritis in children under 5 years of age. Vaccine effectiveness was stratified by age and viral genotype, and vaccine impact was assessed through comparisons of rotavirus positivity before and after Rotavac was introduced in the national immunization program.

The U.S. Centers for Disease Control and Prevention launched its “Free Mind” campaign in July to help people between the ages of 12 and 17 educate themselves about the link between substance abuse and mental health. The campaign materials, accessible at https://www.cdc.gov/free-mind, offer resources like advice from teen peers, informational videos, in-depth fact sheets, conversation starters, and tips for parents and caregivers. There’s even an interactive graphic novel you can play like a video game! As Dr. Allison Arwady, Director of the CDC National Center for Injury Prevention and Control, says, “Talking openly about mental health and substance use, and knowing when to get professional help, is critical to helping teens stay healthy.”

Nature Medicine, Published online: 14 October 2025; doi:10.1038/s41591-025-03992-1

A working group of Academia Europaea proposes the addition of a ‘ring diagram’ in clinical publications for the quick evaluation of translational implications.

Nature Medicine, Published online: 14 October 2025; doi:10.1038/s41591-025-04007-9

Strengthening medical imaging capacity will save lives

Nature Medicine, Published online: 10 October 2025; doi:10.1038/s41591-025-03987-y

Two phase 1 studies report promising outcomes with chimeric antigen receptor (CAR) T cell therapies in patients with systemic lupus erythematosus, but the next stage of development must address key pitfalls around comparator arms and ancillary immune-modulating treatments.