wellness

Nature Medicine, Published online: 08 April 2025; doi:10.1038/s41591-025-03642-6

A map of microbiome–metabolome dynamics in people with type 2 diabetes identifies over 500 blood metabolites associated with impaired glucose control, with approximately one-third linked to an altered gut microbiome.

Nature Medicine, Published online: 08 April 2025; doi:10.1038/s41591-025-03670-2

We show that hematopoiesis in a mouse model of VEXAS syndrome is subverted by inflammation-resilient, senescent-like mutant HSPCs, which have dysfunctional differentiation and undermine hematopoiesis through their proinflammatory progeny. This disease mechanism explains clonal dominance and bone marrow failure (BMF) in patients with VEXAS syndrome and could have translational implications.

Nature Medicine, Published online: 08 April 2025; doi:10.1038/s41591-025-03637-3

A lack of standardized benchmarks is hindering progress and patient benefits

Nature Medicine, Published online: 08 April 2025; doi:10.1038/s41591-025-03646-2

Integrating insights from studies of individual nutrients, foods and diseases with studies of holistic dietary patterns and healthy aging can offer a comprehensive strategy for understanding and promoting public health.

Nature Medicine, Published online: 07 April 2025; doi:10.1038/s41591-025-03618-6

In a large trial involving 180 classes in different contexts in China, interactions with a chatbot provided to parents increased uptake and appointments for human papillomavirus vaccination, with stronger increases in rural areas.

Nature Medicine, Published online: 07 April 2025; doi:10.1038/s41591-025-03613-x

Results from the randomized ProfiLER-02 trial, which compared two gene panels in guiding molecular-based treatment in patients with solid tumors, show that a broader gene panel led to more molecular-based recommended therapies compared to a more limited gene panel.

Nature Medicine, Published online: 07 April 2025; doi:10.1038/s41591-025-03682-y

The scientific community must take a strong and active stand against vaccine revisionism — the false narrative that there is insufficient evidence to support the safety and efficacy of vaccines.

Nature Medicine, Published online: 07 April 2025; doi:10.1038/s41591-025-03681-z

Author Correction: Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry

Nature Medicine, Published online: 04 April 2025; doi:10.1038/s41591-025-03620-y

National implementation of a computed tomographic angiography and AI-diagnostic tool, CT-derived fractional flow reserve (FFR-CT), did not provide significant benefits in reducing mortality but led to fewer invasive coronary angiograms and downstream cardiac tests.

Nature Medicine, Published online: 04 April 2025; doi:10.1038/s41591-025-03631-9

Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare