Time-of-day immunochemotherapy in nonsmall cell lung cancer: a randomized phase 3 trial
Nature Medicine, Published online: 02 February 2026; doi:10.1038/s41591-025-04181-w
In this randomized phase 3 trial, patients with treatment-naive stage III–IV nonsmall cell lung cancer who received sintilimab or pembrolizumab in combination with chemotherapy early in the day (before 15:00 h) experienced longer progression-free survival compared with those receiving late time-of-day infusions.
Time-of-day immunochemotherapy in nonsmall cell lung cancer: a randomized phase 3 trial
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